Mission The Broad Institute of MIT and Harvard is an independent research institution dedicated to accelerating the pace at which the world conquers disease. Our Mission Read about the Broad Mission Priorities The Broad Institute pursues high-impact projects focused on major human diseases. Donor Impact Private philanthropy has played a critical role at the Broad Institute from the very beginning. Zeroing in on Zika Broad scientists have sequenced more than 110 Zika genomes—a key step toward understanding this mosquito-borne virus linked to severe birth defects. Beating Back Cancer Drug Resistance Drug resistance has confounded cancer researchers since the 1940s. For the first time, we have the power to understand the details of how it works. Targeting Cancer’s Achilles Heel MCL1 is one of the most common culprits in cancer. Broad researchers recently identified a small molecule that appears to inhibit the gene’s activity.