Despite major advances in genome sequencing technologies over the past few decades, the majority of individuals with a suspected genetic disease still lack a confirmed diagnosis. This unmet need is especially prevalent for neurogenetic disorders. As a neurologist at Brigham and Women’s Hospital, Vijay will tackle this challenge with his BroadIgnite project. Specifically, he will partner with the Broad Proteomics Platform, deploying machine-learning approaches to develop an assay that detects protein expression outliers from individuals with unsolved rare genetic diseases. Vijay’s goal is to develop a scalable method from clinically-accessible tissues that can both augment novel gene discovery and resolve variant-to-function associations, ultimately shortening the diagnostic odyssey for patients and potentially informing tailored genetic therapies.