Blood cancers arise from mutations in bone marrow stem cells, and nearly 50 percent of these mutations are due to defects in splicing—an essential regulatory process where noncoding regions of the genome and coding regions are joined together to generate various proteins. With BroadIgnite support, Mounica, who is an oncologist at the Dana-Farber Cancer Institute, will deploy a novel approach to systematically map how dysfunctions in splicing impact the progression of blood cancers, eventually informing new much-needed treatment strategies.