While scientists understand how organ-level dysfunctions can affect the body, it remains harder to uncover and therapeutically manipulate their core driving mechanisms—Constantine describes it as seeing a crashed car with a broken windshield but not knowing what caused the crash itself, like worn-out brake pads. His BroadIgnite project seeks to couple experimental platforms, such as photochemistry-based spatially-resolved-omics technologies, with computational approaches to investigate the drivers of cells' beneficial or pathologic responses to disease, with applications across cancer, autoimmunity, and infection.

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