Meet Our Researchers

Oliver Jonas

Associate Member at the Broad Institute of MIT and Harvard
Assistant Professor in Radiology at Harvard Medical School
Laboratory Director at the Department of Radiology at Brigham and Women’s Hospital
Faculty at the Joint Center for Cancer Precision Medicine at Dana-Farber Cancer Institute
The Question

By improving our molecular-based understanding of disease, genomic research can help doctors tailor approaches to individual patients. But brain diseases present an especially thorny challenge. Brain tissue, consisting of a wide variety of cell types, is exceptionally difficult to study, in particular when it comes to how cells malfunction in neurodegenerative and neuropsychiatric diseases. Given these complexities, how can a doctor best determine if an individual’s treatment is on point?

The Approach

To test whether our microdevices can work in the human brain, our lab will first design and build prototypes of the brain-specific devices; next, we will formulate the drugs so that the microdevices can release the proper dosages; then, we will test the devices in animals. We also hope to improve how the microdevices gauge the efficacy of the drugs in real time.